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Pooled data from short-term trials showed similar changes in weight gain, fasting glucose, triglycerides and … Measure weight and assess fasting plasma glucose and lipids when initiating CAPLYTA … In pooled data from short term studies, mean changes from baseline in weight gain, fasting glucose, triglycerides and total cholesterol were similar between CAPLYTA and placebo. Rates of glucose, total cholesterol and weight gain were the same in both groups during the trial. Your health care provider may ask you for a blood sample to check your cholesterol, blood sugar, and hemoglobin A1c (a measure of blood sugar over time) while you take this medication. In pooled data from short term studies, mean changes from baseline in weight gain, fasting glucose, triglycerides and total cholesterol were similar between Caplyta and placebo. Weight gain and other metabolic changes, cardiac problems, or problems with movement or motor coordination were similar in study participants. Metabolic Changes, including hyperglycemia, diabetes mellitus, dyslipidemia, and weight gain. See additional Important Safety Information below. In pooled data from short term studies, mean changes from baseline in weight gain, fasting glucose, triglycerides and total cholesterol were similar between CAPLYTA and placebo. Weight change on CAPLYTA was similar to placebo in short-term trials 1 In 4- to 6-week clinical trials, mean change in body weight from baseline at Day 28 was +3.5 lbs for CAPLYTA 42 mg and +2.9 lbs for placebo 3 In a long-term study of CAPLYTA, patients experienced 1: -4 lbs (average … Measure weight and assess fasting plasma glucose and lipids when initiating CAPLYTA and monitor periodically during long-term treatment. 1 Like. Each drug has its own specific risk profile. Your doctor should check your blood sugar, fat levels and weight before you start and during your treatment with CAPLYTA. May cause metabolic changes, including hyperglycemia, diabetes mellitus, dyslipidemia, and weight gain. Disadvantages of Taking Caplyta In 4- to 6-week trials, patients on CAPLYTA experienced metabolic, EPS, prolactin, and weight changes similar to placebo1,3 Antipsychotic drugs have been reported to cause: Hyperglycemia, … Pharmacology, adverse reactions, warnings and side effects. We understand that side effects might be a concern when thinking about starting a new medicine. Neuroleptic malignant syndrome (NMS): high fever, confusion, changes in your breathing, heart rate, and blood pressure, stiff muscles, and increased sweating; these may be symptoms of a rare but potentially fatal condition. Very similar rates of Metabolic shifts, I.e weight gain. In the clinical trials people actually lost weight compared to placebo. Your doctor may do blood tests during the first few months of treatment with CAPLYTA. © 2020 Intra-Cellular Therapies, Inc. All rights reserved. Others include changes in metabolism, blood pressure, and weight loss, or gain. This site is for US healthcare professionals only. A New Drug Could Halt Weight Gain in Patients Taking These Antipsychotics Alkermes Plc's ALKS 3831 could help patients that take atypical antidepressants avoid gaining weight. Individuals may be gaining weight for other reasons, such as: an increase in appetite due to an improved mood the natural weight gain that results from aging overeating, hardly exercising, or … Discontinue CAPLYTA if clinically appropriate. The incidence of extrapyramidal symptoms was 6.7% for Caplyta and 6.3% for placebo. Antipsychotic drugs have been reported to cause: Contraindications: CAPLYTA is contraindicated in patients with known hypersensitivity to lumateperone or any components of CAPLYTA. A useful product and positive CAPLYTA Reviews are available too they scare me it unique that! Show the medicine to be a useful product and positive CAPLYTA Reviews are available.! 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